Wall Street is poised to open with more losses Tuesday as artificial-intelligence -related shares continued to drag markets lower. Futures for the S&P 500 fell 0.6%, while futures for the Dow Jones Industrial Average lost 0.

In the deal announced Tuesday, Nvidia and Microsoft will invest up to $10 billion and as much as $5 billion, respectively, in AI developer Anthropic ( ANTH.PVT ). Anthropic will buy $30 billion of compute capacity from Microsoft Azure, and Anthropic and Nvidia will collaborate on design and engineering, the companies said.

One of these investing greats is billionaire Philippe Laffont, who's overseeing close to $41 billion in AUM at Coatue Management, as of Sept. 30. Laffont is often fairly active from one quarter to the next, and he's a big fan of growth companies that have the potential to disrupt their respective industries.

The U.S. stock market is slumping as superstars swept up in the mania around artificial-intelligence technology keep weakening. The S&P 500 fell 1.5% Thursday.

As Heard on the Street concludes, Big Tech’s AI ambitions promise long-term returns but introduce new uncertainties. With investment cycles stretching over years and the threat of underutilized infrastructure looming, the sector’s transformation is only beginning.

Wall Street will get a sense of where the billions of dollars being spent on artificial intelligence are going when Nvidia Corp. reports its earnings after the bell on Wednesday. How the sinking

Nvidia has grown to become the largest stock on Wall Street and briefly topped $5 trillion in value. That means its stock movements carry more weight on the S&P 500 than any other stock, and it can single-handedly steer the index’s direction some days.

Nvidia reported more eye-catching numbers for its fiscal third quarter Wednesday, with net income jumping 65% and revenue increasing 62% from a year earlier