Mayer typically serves as the Raiders' No. 2 tight end when he's available, but his absence will loom larger in Week 5 since starter Brock Bowers (knee) is inactive for the first time in his career. With Bowers and Mayer in street clothes,

The Week 5 matchup for Michael Mayer and the Las Vegas Raiders has them going head to head against the Indianapolis Colts at 1 p.m. ET on Sunday, Oct. 5. Mayer is currently listed on this week's injury report (out, concussion).

According to ESPN, both tight end Michael Mayer and cornerback Eric Stokes were on the practice field Wednesday. #Raiders TE Michael Mayer (concussion) and CB Eric Stokes (knee) are practicing.

The Raiders elevated Albert Okwuegbunam and Carter Runyon amid Michael Mayer’s injury concerns, while RB Ashton Jeanty continues to struggle.

Mayer (concussion) is listed as questionable for Sunday's game against the Colts, Ryan McFadden of ESPN.com reports.

In Week 3, tight end Michael Mayer was forced to leave the game early due to a concussion. He has missed practice all week, as he has been in the NFL’s concussion protocol. Unfortunately for the Raiders, he’s not going to be ready in time for the Bears game. The team announced on their Friday injury report that Mayer has officially been ruled out.

The Raiders will be without tight end Michael Mayer for the second straight game Sunday against the Indianapolis Colts because of a concussion.