49ers vs. Rams on Thursday Night Football: San Francisco stuns L.A. with critical fourth-and-1 stop in overtime to win 26-23

The 49ers pulled off one of the shocking upsets of the early NFL season, ignoring multiple injuries for a 26-23 overtime victory over the Rams.
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49ers vs. Rams highlights: San Francisco pulls out miracle win in NFL Week 5 game

The San Francisco 49ers stayed atop the NFC West with a miracle win over the Los Angeles Rams in Week 5. Here are the highlights.

San Francisco 49ers at Los Angeles Rams: Predictions, picks and odds for NFL Week 5 game

USA Today's NFL experts make their picks for a Week 5 showdown between the Los Angeles Rams and San Francisco 49ers
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49ers have no reason to rush Brock Purdy back

San Francisco 49ers quarterback Brock Purdy missed Thursday night's game against the Los Angeles Rams due to a lingering toe injury, and it sounds like he could be facing another multi-game absence.

Rams vs. 49ers score, takeaways: Injury-depleted San Francisco fends off mistake-prone Los Angeles in overtime

The 49ers defeated the Rams 26-23 in overtime behind a terrific performance from Mac Jones, another workmanlike effort from Christian McCaffrey, a career night from Kendrick Bourne and several clutch red zone plays from their defense.

NFL Thursday schedule, TV, how to watch San Francisco 49ers vs Los Angeles Rams game today

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

49ers vs. Rams predictions, picks and best bets for NFL Thursday Night Football: NFC West rivalry in primetime

These coaches are friends who joined the division at the same time, are considered offensive geniuses and have had successful tenures as coaches of their respective teams. When they meet on NFL Thursday Night Football, McVay’s Rams are in much better shape when it comes to team health and availability.
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