Scientists at the University of Sydney have uncovered a malfunctioning version of the SOD1 protein that clumps inside brain ...

Groundbreaking research by Sydney University found a new brain protein involved in Parkinson’s disease and a way to modify it ...

Explore the latest research on Parkinson's and a key brain protein that may lead to new treatments for this common condition.

Groundbreaking research by the University of Sydney has identified a new brain protein involved in the development of ...

A newly discovered brain protein linked to Parkinson’s offers hope for targeted therapies that could slow or prevent disease ...

The disease, which is caused by mutations in the SOD1 gene, accounts for approximately 10% to 20% of genetic ALS cases and 1% to 2% of sporadic ALS cases, according to the ALS Association. 7.

Dokholyan explained that SOD1 typically exists as a dimer, a protein composed of two identical units. Under certain conditions, SOD1 will change its shape and reassemble itself into a three-unit ...

SOD1-G85 seems to act as a sort of “acceptor” for SOD1-propagated misfolding in a way that the wild-type protein does not. Cashman speculated that in an aging person, wild-type SOD1 might become more ...

Using the misfolded SOD1 antibody C4F6, Bosco discovered misfolded SOD1 in four out of nine sporadic ALS cases. The work suggests that at least some ALS cases manifest deformed SOD1, even though the ...

The U.S. Food and Drug Administration approved a new drug Tuesday to treat a rare form of amyotrophic lateral sclerosis, or ALS.. The drug Qalsody (tofersen) is expected to help people with a very ...

The decision on the SOD1 ALS program does not impact Voyager’s other gene therapy programs; the Company continues to expect IND filings in 2025 from Neurocrine Biosciences for the program in ...

However, an Iowa State University research team found SOD1’s protective benefits dramatically weaken when levels of tau proteins – a hallmark of Alzheimer’s disease – increase. Based on the results, ...