The San Francisco 49ers released their latest injury updates headed into the Week 5 contest versus the Los Angeles Rams.

The San Francisco 49ers head into Thursday Night Football against the Los Angeles Rams, with a 3-1 record, matching their division rivals. It’s a big early-season matchup, and the 49ers aren’t hiding anything,

Keep up with the 2025 NFL season on FOX Sports. Prior to the final injury report, which lists players as questionable, doubtful or out, NFL teams use practice designations to update player injury statuses. This can include DNP (did not participate), LP (limited participant) or FP (full participant).

The 49ers put 12 players on their estimated report, listing seven of them as non-participants. Brock Purdy was estimated as DNP, as were Jauan Jennings and Ricky Pearsall. Purdy isn't certain to play this week, according to coach Kyle Shanahan, so his status will be monitored in the coming days.

The San Francisco 49ers beat the Los Angeles Rams in what looked like an improbable outcome. San Francisco was far more shorthanded than their division rivals due to injuries, but still pulled off the upset. While the team is going to be happy with the win, they will have to evaluate a new slew of injuries .

Fantasy Impact: ESPN's Kris Rhim posits that the Chargers could be forced to lean on rookie running back Omarion Hampton in a way they "didn't anticipate" in 2025. It would certainly make sense after Hampton erupted for 135 yards from scrimmage and a touchdown against the Broncos. Hampton vaults into the RB1 tier for the remainder of the season.

San Francisco 49ers tight end George Kittle is eligible to be activated off injured reserve to play in the team's Week 6 matchup with the Tampa Bay Buccaneers, but that doesn't necessarily mean a return will happen against Tampa Bay.

The 49ers are down yet another player. Defensive tackle Kalia Davis broke his hand in Thursday night's win over the Rams, and will undergo surgery on Friday, ac