A San Francisco team riddled with injuries hits the road to play the Los Angeles Rams in an NFC West battle of 3-1 teams. Both are off to a quick start this season, though the 49ers are in a bit of a health quandary,

The San Francisco 49ers have promoted quarterback Adrian Martinez from the practice squad to the active roster ahead of Thursday night's road game against the Los Angeles Rams.

Will Los Angeles continue to roll following their big win last week?

Of the 147 offensive plays of this mesmerizing car wash, it boiled down to fourth-and-1 at the 49ers’ 11-yard line with 3:41 left in overtime. The 49ers had taken the lead with a field goal on overtime’s opening possession, and the rival Rams tried to replicate Super Bowl LVIII with a game-winning touchdown in response.

Thursday Night Football kicks off when the Los Angeles Rams (3-1) meet a fellow NFC West foe, San Francisco 49ers (3-1), on Thursday, October 2, 2025 at SoFi Stadium.

'A game of inches!' - 49ers beat Rams in overtime thriller.