49ers, Brock Purdy and Los Angeles Rams
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As for the Cardinals, their running back contingency plan is being tested. James Conner is out for the year, which opened the door for second-year back Trey Benson. Unfortunately for the Cards, Benson injured his ankle last week, so Michael Carter and Emari Demercado are expected to get the bulk of the touches out of the backfield moving forward.
The 49ers kept giving away their lead until finally making a stop at their 11-yard line to defeat the Rams 26-23 in overtime.
Keep up with the 2025 NFL season on FOX Sports. Prior to the final injury report, which lists players as questionable, doubtful or out, NFL teams use practice designations to update player injury statuses. This can include DNP (did not participate), LP (limited participant) or FP (full participant).
The San Francisco 49ers were hoping to get some version of good news throughout the week on their practice participation report. That wasn't the case Tuesday where a handful of stars remained absent from the sessions.
The final injury report leading into Week 5's Thursday Night Football matchup between the Rams and the 49ers at SoFi Stadium.
Former 49ers safety Donte Whitner explains what San Francisco is missing on offensive without receiver Deebo Samuel.
The 49ers (3-1) committed four turnovers and the Jacksonville Jaguars (3-2) had none Sunday as the Niners fell 26-21.
In a rough Week 4 performance for San Francisco 49ers rookies, the most ignominious development was seeing Upton Stout's potential game-changing interception disappear on a questionable flag.