Starting quarterback Brock Purdy (toe) will miss the contest after returning from injury in Week 4 while starting receivers Ricky Pearsall (knee) and Jauan Jennings (rib/ankle) are also poised to be out of action.

The San Francisco 49ers never really got going in their Week 4 loss vs. the Jacksonville Jaguars. Here are the highlights.

The Los Angeles Rams are hosting the San Francisco 49ers to open Week 5 in a battle of 3-1 NFC West clubs on Thursday, Oct. 2.

Brock Purdy remained on the 49ers injury report with toe and shoulder issues. Is Purdy going to play Thursday night against the Rams?

The San Francisco 49ers reveal quarterback Brock Purdy's status for Thursday's game against the Rams after toe and shoulder injuries.

Thursday Night Football in Week 5 features a huge NFC West battle between the 3-1 Los Angeles Rams and the 3-1 San Francisco 49ers. Three teams in the NFC West

The Arizona Cardinals and San Francisco 49ers played a physical, ploddy game on Sunday. With both teams shorthanded and suffering injury losses during the game, the 49ers came away with a 16-15 last-second win. Eddie Pineiro made a 35-yard field goal as time expired.

Get the best Jaguars vs. 49ers predictions ahead of Sunday's clash at Levi's Stadium. Free NFL picks for September 28.

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The San Francisco 49ers did little right Sunday, with only the defense showing any signs of life as they fell to the Jacksonville Jaguars 26-21 at Levi's Stadium.