Since sustaining the injury during the first week of the NFL season, Kittle has been placed on injured reserve.

San Francisco 49ers star George Kittle will likely miss Week 6. His return from a hamstring injury is now a long shot for the upcoming game. Coach Kyle Shanahan confirmed Week 7 against Atlanta is a more realistic target.

The Falcons have seen a tremendous year-over-year improvement from their defense, but their post-bye week showdown with the Bills will be its biggest test yet.

Sean McVay ’s 3-1 Los Angeles Rams took on a banged-up San Francisco team that was playing without quarterback Brock Purdy (turf toe), wide receivers Ricky Pearsall (knee) and Jauan Jennings (ankle/ribs). The 49ers went on to win a thriller, 26-23 in overtime, after stopping Kyren Williams on a 4th-and-1 play in the red zone.

The 49ers and Rams are battling for control of the NFC West on "Thursday Night Football." Here's where to watch the divisional rivals face off.

Mike Florio and Chris Simms preview a Week 5 Sunday Night Football showdown between the Patriots and Bills at Highmark Stadium, analyzing a shocking spread and sharing why Josh Allen's squad is on upset alert at home.

The San Francisco 49ers and Los Angeles Rams will meet at SoFi Stadium on Thursday. Here's what fantasy owners should do with their 49ers in Week 5.