San Francisco 49ers head coach Kyle Shanahan didn't have much good news in his injury updates on his conference call after the team's Week 5 win.

Kyren Williams was stopped on a fourth-and-1 at the 49ers' 1-yard line in overtime to seal the win for San Francisco. Marques Sigle and Deommodore Lenoir combined to make that sensational game-ending tackle on a night that the 49ers were without Brock Purdy, George Kittle, Juwan Jennings, Ricky Pearsall, Brandon Aiyuk, and Nick Bosa .

Kyle Shanahan flexed his muscles against the Rams in what was one of his most impressive victories as a head coach

The 49ers took down the Rams in overtime in their Week 5 "Thursday Night Football" matchup. Here's how it happened.

Collins sprained his knee during the 49ers ' 23-20 overtime win over the Rams on Thursday, Nick Wagoner of ESPN.com reports.

San Francisco 49ers defensive tackle Alfred Collins, bottom, celebrates with teammates after recovering a fumble against the Los Angeles Rams during the second half of an NFL football game, Thursday, Oct. 2, 2025, in Inglewood, Calif.

On a night to remember, here are the three players who were graded the highest in San Francisco's overtime win against Los Angeles

The San Francisco 49ers got out to an early lead with another big game from Mac Jones, hung tough with key defensive stops and pulled off a 26-23 OT win over the Los Angeles Rams.