What makes the assumption even more impressive is that San Francisco almost beat Jacksonville. They had a few ugly passes by an injured Purdy, and they allowed a punt return for a touchdown. Still, they were within one score of winning the game.

Eddy Piñeiro hit a 41-yard field goal in overtime before San Francisco stopped Kyren Williams on fourth down with 3:36 to play, and the short-handed 49ers hung on for a thrilling 26-23 victory over th

The fumble was forced by 49ers rookie Alfred Collins who threw a perfect punch at the football to knock it loose. If Williams had scored a touchdown, it would have put the Rams up 27-23 with just 1:05 left to play, but instead, the 49ers took over possession at their own 1-yard line.

Sep 28, 2025; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) leaves the field after the game against the Indianapolis Colts at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images / Jayne Kamin-Oncea-Imagn Images

The San Francisco 49ers went down to Los Angeles to take on the Rams on Thursday Night Football in Week 5. The Rams were favored heading into the game as the 49ers were dealing with all kinds of injuries on the roster. Most importantly, starting quarterback Brock Purdy was out, as were wide receivers Ricky Pearsall and Jauan Jennings.

Of the 147 offensive plays of this mesmerizing car wash, it boiled down to fourth-and-1 at the 49ers’ 11-yard line with 3:41 left in overtime. The 49ers had taken the lead with a field goal on overtime’s opening possession, and the rival Rams tried to replicate Super Bowl LVIII with a game-winning touchdown in response.

The 49ers’ mechanical, infuriating offensive style has in the past set up the Rams to make self-inflicted mistakes, and it often felt like that bled into every phase of the team. It was the same story Thursday as the unforced errors compounded.

San Francisco running back Christian McCaffrey made 49ers history with his dominant performance over the Los Angeles Rams.