Appendicitis is a condition in which the appendix, a finger-shaped pouch that opens into the large intestine, becomes swollen and filled with pus. Appendicitis can be caused by a bacterial infection ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

We conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary ...

At first glance, the results of a recent meta-analysis published in JAMA Pediatrics would indicate immediately operating on a child is the most effective treatment for uncomplicated acute appendicitis ...