As always, there are a ton of games on TV. For Cardinals fans, the ones that might have the most intrigue are top-25 teams and teams in the Big 12. But here is a graphic of the bigger games and networks from 506 Sports. Here is a rundown of the top-25 games on Saturday.

Week 4 of the NFL season begins with an NFC West showdown as the Arizona Cardinals host the Seattle Seahawks on Thursday Night Football!

Thursday Night Football's Arizona Cardinals vs Seattle Seahawks NFL Week 4 game on Sept. 25, 2025, will feature the Cardinals' new Rivalries uniform.

Get our best Seahawks vs. Cardinals predictions, picks, and odds for Thursday Night Football on September 25. Jaxon Smith-Njigba will power Seattle to victory.

Pregame analysis and predictions of the Tennessee Titans vs. Arizona Cardinals NFL game to be played on October 5, 2025 on ESPN.

Which NFL teams have the best chances of winning their games on the NFL Week 5 schedule? ESPN Analytics has revealed its Matchup Predictor numbers for the 14 games in the league this week, and they offer some interesting win probabilities.