It's the New England Patriots vs Buffalo Bills this Sunday at Highmark Stadium in an AFC East thriller. Live coverage begins at 7 PM ET on NBC and Peacock.

The month of October and Week 5 of the 2025 NFL season have arrived, and the San Francisco 49ers treated the football world to a stunning 26-23 overtime road win over the Los Angeles Rams despite a depleted depth chart.

The Buffalo Bills have a chance to go 3-0 in the division early on when they host the New England Patriots in what looms to be a tough outing with Stefon Diggs making his return to Highmark Stadium.

It's a busy uniform slate in Week 5 of the NFL season, led by the Buffalo Bills debuting their Rivalry threads.

Entering the season, it appeared as though the top-heavy AFC would be a three-team fight to the finish, but with the 1-3 Ravens and 2-2 Chiefs off to uncharacteristically slow starts, Buffalo now looks like the class of the conference all by itself. And winning the conference could make a world of difference once the Bills reach the postseason.

The Atlanta Falcons have seen a tremendous year-over-year improvement from their defense, but their post-bye week showdown with the Buffalo Bills will be its biggest test yet.

The Buffalo Bills could bolster their offense around QB Josh Allen with a trade for a 1,000-yard WR ahead of the NFL trade deadline.