The Bills lead the league in multiple categories, including rushing yards per game (163.0), rushing yards (489) and rushing touchdowns (7). They are fifth in passing yards (771) and Josh Allen has only taken four sacks and has yet to throw an interception.

Preview the Buffalo Bills' NFL Week 4 matchup with the Saints, including live stream, TV channel, odds, and game information.

NFL RedZone — an around-the-horn live highlight show demonstrating all the action on NFL Sunday — is back for Week 4 of the 2025 season.

The NFL season continues with the Buffalo Bills hosting the New Orleans Saints Sunday. Start time, where to watch, streaming and NFL schedule.

The Saints travel to Buffalo in their Week 4 matchup and this is your one-stop shop to find out how to follow the action!

The New Orleans Saints, led by quarterback Spencer Rattler, face the Buffalo Bills, led by quarterback Josh Allen on Sunday, Sept. 28, 2025 at Highmark Stadium in Orchard Park, N.Y.

The AFC-leading Buffalo Bills are off to a 4-0 start and have won 14 straight regular-season home games in preparing to host their division rival New England Patriots on Sunday night

The Buffalo Bills will be breaking out special uniforms for Sunday's AFC East showdown with the New England Patriots.