The Lions are the opponent in Buffalo's home opener.

The 2026 Detroit Lions schedule won't be fully released until Thursday, but we know for sure they'll be playing the Buffalo Bills in Week 2. Amazon Prime announced Monday the Lions will play at ...

Detroit Lions 2026 schedule in Week 2 will see them visit Buffalo Bills on Thursday Night Football in opener of the new $2.2 ...

Prime Video’s Thursday Night Football opener for the 2026 NFL season will also open a new stadium. Amazon announced at its upfront presentation on Monday night that the Week 2 game on Sept. 17 between ...

The Buffalo Bills will break in their new $2 billion Highmark Stadium in Week 2 against one of the top teams in the NFC.

Whether the Bills and Lions emerge as Super Bowl contenders remains to be seen, but it's certainly an exciting matchup to kick off TNF for the 2026 season. So long as the Bills ha ...

Primetime kickoff: Buffalo will christen its new Highmark Stadium by hosting Detroit on September 17 in the season’s first Thursday Night Football game. Teams seeking redemption: The Bills and Lions ...

The Buffalo Bills will host the Detroit Lions in the first game at Buffalo's new Highmark Stadium. Here's when: ...

The full 'TNF' schedule for this upcoming NFL season ...

The last time these teams met was in Week 15 of the 2024 season, when the Bills beat the Lions 48-42 at Ford Field, giving Detroit one of its two losses that year. This year’s Week 2 game will be the ...