Get the best Patriots vs. Bills predictions ahead of Sunday Night Football from Highmark Stadium. Free NFL picks for October 5.

The unbeaten Bills host the improved Patriots on Sunday Night Football. Here's Sal Maiorana's preview of the game and his prediction.

The month of October and Week 5 of the 2025 NFL season have arrived, and the San Francisco 49ers treated the football world to a stunning 26-23 overtime road win over the Los Angeles Rams despite a depleted depth chart.

The Buffalo Bills look to extend their home-game winning streak against division rivals when the team takes on the New England Patriots in Week 5. The Bills have won 11 straight games against AFC East opponents in Buffalo. It’s the longest streak since the Tom Brady-led Patriots racked up 17 consecutive wins.

Get a full Patriots vs. Bills Sunday Night Football preview with betting odds, fantasy projections, and key player props for Drake Maye, James Cook, and more.

It's the New England Patriots vs Buffalo Bills this Sunday at Highmark Stadium in an AFC East thriller. Live coverage begins at 7 PM ET on NBC and Peacock.

McDermott blitzed Maye again and again in their lone matchup last season. The Bills head coach dialed up extra rushers on 42.5 percent of Maye’s dropbacks, which was Buffalo’s highest blitz rate in any game last season. Maye completed just six of his 16 attempts against the blitz for 67 yards and a pick.

The New Orleans Saints (0-3) visit the Buffalo Bills (3-0) Sunday at Highmark Stadium in Orchard Park, New York. Kickoff is scheduled for 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Saints vs. Bills odds and make our expert NFL picks and predictions for the best bets.

Violetta is an adorable German Shepherd puppy full of joy. Watch the shy and sassy sweetie pick a champion when the Buffalo Bills face the New England Patriots on Sunday 5.

The Miami Dolphins and Buffalo Bills play on Thursday, Sept. 18, at the Bills' Highmark Stadium in a game on the NFL Week 3 schedule. Which team will win the NFL Week 3 game on Thursday Night Football? The Bills are a 12.5-point favorite over the Dolphins ...