The New Orleans Saints take on the Bills in Buffalo at noon on Sunday with the road team serving as a heavy underdog. This is the place to keep up with the score and live updates. The Bills (3-0) are 14.5-point favorites over the Saints, who are 0-3 entering the game.

The Bills committed 11 penalties but pulled away in the fourth quarter to beat the Saints. Here are the highlights.

It's the New England Patriots vs Buffalo Bills this Sunday at Highmark Stadium in an AFC East thriller. Live coverage begins at 7 PM ET on NBC and Peacock.

The Buffalo Bills have a chance to go 3-0 in the division early on when they host the New England Patriots in what looms to be a tough outing with Stefon Diggs making his return to Highmark Stadium.

It’ll feel like summer in Orchard Park this weekend, but the Buffalo Bills are planning a blizzard.

On Monday, Bills head coach Sean McDermott shared that Johnston is dealing with foot and ankle injuries and will miss some time. He added that the team will work out new punters this week to punt against the Patriots.

USA Today's NFL experts make their picks for a Week 5 showdown between the Buffalo Bills and New England Patriots

The Bills host the Patriots in an AFC East showdown on Sunday Night Football. Here's the broadcast and betting information.

The Buffalo Bills rolled the dice in free agency, and through the first four games of the 2025 season, it appears they won the gamble.

Hear from Buffalo Bills head coach Sean McDermott regarding safety Cole Bishop's crucial interception in the Week 4 win over the New Orleans Saints.