The NFL season continues with the Buffalo Bills hosting the New Orleans Saints Sunday. Start time, where to watch, streaming and NFL schedule.

The Bills and Saints play Sunday in Week 4 of the 2025 NFL season.

The Bills lead the league in multiple categories, including rushing yards per game (163.0), rushing yards (489) and rushing touchdowns (7). They are fifth in passing yards (771) and Josh Allen has only taken four sacks and has yet to throw an interception.

Preview the Buffalo Bills' NFL Week 4 matchup with the Saints, including live stream, TV channel, odds, and game information.

No, the Buffalo Bills don't play on Sunday, Sept. 21. They already played their Week 3 game on Thursday, Sept. 18, when they defeated the Miami Dolphins. The Bills' next game is Sunday, Sept. 28. They'll be at home against the New Orleans Saints. It will be a 1 p.m. kickoff. That game is scheduled to be broadcast on CBS.

NFL RedZone — an around-the-horn live highlight show demonstrating all the action on NFL Sunday — is back for Week 4 of the 2025 season.

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The AFC-leading Buffalo Bills are off to a 4-0 start and have won 14 straight regular-season home games in preparing to host their division rival New England Patriots on Sunday night