The American Society of Regional Anesthesia and Pain Medicine has published a practice advisory on local anesthetic systemic toxicity (LAST) called “Guidelines for the Management of Severe Local ...

A new study published in the Feb. 2012 issue of Anesthesiology found that the type of lipid emulsion used to reverse toxicity of local anesthetics may change the effectiveness of the reversal, ...

All current local anesthetics block sensory signals—pain—but they also interrupt motor signals, which can be problematic. For example, too much epidural anesthesia can prevent mothers in labor from ...

Poisonings and deaths linked to the use of the local anaesthetic lidocaine have nearly tripled in the US over the past decade, finds an analysis of National Poison Data System (NPDS) reports, ...

Inspired by the natural bonding between a class of potent local anesthetics called site-1 sodium channel blockers (S1SCBs) and peptide sequences on the sodium channel in the nerve cell membrane, ...

Please provide your email address to receive an email when new articles are posted on . Use of tumescent anesthesia allows for equal anesthetic distribution across large areas while decreasing the ...

Patients with traumatic injuries who are treated in the emergency room are susceptible to opioid-related adverse drug effects. Increased use of regional anesthesia can be helpful in the effort to ...

An impressive new study, led by scientists from the Boston Children's Hospital, has developed a novel method to tame one of the world's most potent toxins, tetrodotoxin, commonly found in the ...

Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and ...