Researchers have identified how to encourage tumors to build their own immune hubs—structures that look and function like ...

In experiments with mouse models of breast, pancreatic and muscle cancers, researchers report new evidence that a novel means ...

Scientists have engineered Salmonella bacteria to self-destruct inside tumors, releasing signals that spark powerful immune ...

In this interview, we spoke with Associate Professor Diana Mechtcheriakova about how lymphoid structures and germinal centers are unlocking new prognostic insights into colorectal cancer, and with ...

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a ...

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a ...

TLSs are highly organized structures that typically appear as clusters of B-cells containing FDCs. These clusters are then surrounded by T-cells and HEVs as shown schematically in Figure 1. We ...

Tissue samples from head and neck cancer patients that show tumor “neighborhoods.” The image on the left is more diffuse because it has dysfunctional, exhausted immune cells, while the image on the ...

A little-known tissue composed of a cluster of immune cells could offer novel insights into the development of neurological disorders. Meninges' immune system changes with age and neurodegeneration.

In almost all solid tumors—i.e. cancers with a solid tissue structure—the detection of tumor cells in the lymph nodes is considered a decisive marker for the progression of the disease. Lymph node ...