Fading Indianapolis may also be part of a greater NFL survivor pool strategy, which sees the Colts play a struggling Titans team in a couple of weeks. The model projects the Colts to win 74% of the time, which is lower than other teams this week, making Indianapolis a team to avoid in NFL survivor pool picks. See which team to pick instead here .

Without further ado, here are our picks for Week 5.

Week 5's Thursday Night Football matchup between the Rams and 49ers will air live on Amazon Prime Video. The action will not be available on traditional TV. NFL fans can tune into the Rams vs. 49ers game live on SiriusXM channels 225 (Rams) and 226 (49ers).

With Joe Flacco getting benched this week, that means that Dillon Gabriel will now become the 41st player to start at quarterback for the Browns since they returned to the NFL in 1999. That's the most different starting quarterbacks by any team over that span (The Commanders rank second with 35 different starters).

Bold predictions for Giants-Saints Week 5 matchup, featuring rookie quarterback Jaxson Dart's first career road start

Patriots vs. Bills, Broncos vs. Eagles and Buccaneers vs. Seahawks highlight the upcoming slate. Here's the full Week 5 NFL schedule.

The NFL season is four games in, and it's time to check in on who has the lead in the Offensive Player of the Year race.

Each week, every non-primetime game (in other words, the games that aren't played on Thursday Night Football , Sunday Night Football, or Monday Night Football) is broadcast on either CBS or Fox at 1 p.m. ET or around 4 p.m. ET. This means fans everywhere will have at least two games shown on their screens every Sunday afternoon during the season.