Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

Jimmie Kaylor shares his top NFL DFS picks, daily fantasy optimal lineups, and NFL DFS stacks for Rams vs. 49ers on 'Thursday Night Football'

These coaches are friends who joined the division at the same time, are considered offensive geniuses and have had successful tenures as coaches of their respective teams. When they meet on NFL Thursday Night Football, McVay’s Rams are in much better shape when it comes to team health and availability.

USA Today's NFL experts make their picks for a Week 5 showdown between the Los Angeles Rams and San Francisco 49ers

This article originally published at Ex-NFL ref says 49ers-Rams crew missed call on pivotal tackle of Mac Jones.

Jones was only playing because Brock Purdy, the quarterback signed to a $265 million contract in the offseason, had been hurt in the season opener, and in the process joined a rash of big names sidelined by injury — from Cincinnati’s Joe Burrow, to the Giants’ Malik Nabers, to potentially two-time MVP Lamar Jackson in Baltimore, as well.

Series History: San Diego State leads, 22-15, and has won 7 of last 9

Chief National Reporter Steve Wyche and NFL Network analyst Daniel Jeremiah discuss what to expect in Week 5 matchup between the San Francisco 49ers and Los Angeles Rams on "NFL Gameday Kickoff".