San Francisco running back Christian McCaffrey made 49ers history with his dominant performance over the Los Angeles Rams.

Mac Jones, Kendrick Bourne and the crew rallied for a dramatic 26-23 overtime win over the Los Angles Rams on Thursday night thanks to a fourth-down stand in the extra session.

Week 5 of the 2025 NFL season starts with a Thursday Night Football game between two NFC West teams, the San Francisco 49ers and the Los Angeles Rams. The game is set to take place at SoFi Stadium in Inglewood,

The 2025 NFL season rolls on with a full Week 5 slate. After the 49ers and Rams kicked things off on Thursday, it’s time to get ready for the rest of the week’s NFL action. Tracking how much betting lines move during an NFL week can provide useful information to bettors.

NFL Insider Tom Pelissero gives an injury update on Washington Commanders quarterback Jayden Daniels and wide receivers Terry McLaurin and Deebo Samuel ahead of their Week 5 matchup against the Los Angeles Chargers.

NFL Week 5 begins with the Los Angeles Rams hosting the San Francisco 49ers on Thursday Night Football tonight. Start time, NFL TV schedule and how to watch.

Sam Farmer makes his picks and predictions for NFL Week 5, with the Eagles defeating the Broncos, the Rams beating the 49ers and the Chiefs winning on Monday.