As the first clinical trial of the drug novobiocin is about to open for patients with cancers carrying BRCA gene mutations, new research at Dana-Farber Cancer Institute shows the drug poses a double ...

Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer. Resistance to alkylators may potentially be overcome by drugs that inhibits DNA repair, thus ...

BOSTON - An antibiotic developed in the 1950s and largely supplanted by newer drugs, effectively targets and kills cancer cells with a common genetic defect, laboratory research by Dana-Farber Cancer ...

The present report deals with the in vitro anti-microbial activity of novobiocin and its efficacy in the treatment of a variety of surgical infections due to staphylococci and other gram-positive ...

THE clinical use of novobiocin is increasing because of its effectiveness in the treatment of staphylococcal infections. Toxic reactions 1, 2 include mild diarrhea (37 per cent), skin rashes (8.9 per ...