In the early days of pharmaceutical research, discoveries were often made by chance. Take for example the discovery of penicillin by Fleming in the 1930s. Fleming observed that a certain mold stopped ...

This new study, which will appear in the June 2005 issue of The American Naturalist, asserts that an individual could use his/her genotype as an informative cue when "deciding" which phenotype ...

Phenotypic screening is a drug discovery approach that identifies bioactive compounds based on their ability to alter a cell or organism’s phenotype (observable characteristics) in a desired manner.

Developmental programming has gained considerable attention in animal sciences because early conditions can shape how ...

The ability to make induced pluripotent stem cells (iPSCs) from adult human somatic cells and use those iPSCs to produce any cell type in the human body opens new avenues for drug discovery. Human ...

Genotype-phenotype models (GPM) of crops represent a significant advancement in understanding the intricate relationship between genetic information and physiological processes in plants. These models ...

The Simons Foundation Autism Research Initiative (SFARI) has released phenotypic and genetic data from the Autism Inpatient Collection (AIC), a cohort of more than 1,500 youth participants ages 4 to ...

Figure 1. Optical pooled screens and PerturbView. a) Optical pooled screens (OPS) use targeted in situ sequencing of perturbations to link phenotypes and genotypes from a pooled library, making it ...