Background. Progressive multifocal leukoencephalopathy (PML) is a rare, severe, otherwise fatal viral infection of the white matter of the brain caused by the polyomavirus JC virus, which typically ...

Use of a genetic risk test for patients considering immunosuppressive therapies associated with development of progressive multifocal leukoencephalopathy may help reduce incidence of disease, ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

Kamble et al. 1 recently provided a review of cases of central nervous system graft-versus-host disease (CNS GVHD). The authors conclude that ‘when relapse of a CNS neoplastic process, opportunistic ...

In progressive multifocal leukoencephalopathy (PML) the JC virus (JCV) load in the cerebrospinal fluid (CSF) is discussed as a parameter for disease progression. To investigate the evolution of viral ...

Phase I study of bendamustine combined with rituximab in relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (B-NHL). Background: Rituximab is an anti-CD20 monoclonal antibody which has ...

CE-VST01-JC is an allogeneic, off-the-shelf, T cell therapy targeting the JC virus, the cause of PML, a rare, rapidly progressing, often fatal illness for which there are no approved treatment options ...