Bryan Rockwood previews the Thursday Night Football matchup of the 49ers vs. the Rams, looking for the top fantasy options.

Get Rams vs. 49ers TNF odds, betting lines, and fantasy projections featuring Puka Nacua, Christian McCaffrey, and key matchups to watch in Week 5.

To this point in the season, the team dealing with the most injuries is arguably the 49ers again, though the Ravens and Bengals have had their seasons thrown off with injuries too. The 49ers and coach Kyle Shanahan did a great job to get to 3-0 given all the players who were out or playing hurt,

Los Angeles Rams inside linebacker Nate Landman (0:00), outside linebacker Byron Young (1:15), wide receiver Davante Adams (2:55), running back Kyren Williams (4:54), and wide receiver Puka Nacua (6:51) react to tonight's loss to the San Francisco 49ers.

Mike Florio and Chris Simms preview a Week 5 duel between the 49ers and Rams at SoFi Stadium, detailing how injuries will impact Kyle Shanahan's offense and explaining why Los Angeles is "moving in the right direction.

McVay passed on a potential game-tying field goal deep into overtime against the San Francisco 49ers, needing one yard to keep the Rams' drive alive in the red zone, but Robert Saleh's defense stopped Kyren Williams and walked away with the upset 26-23 win.

Here's everything you need to know when the San Francisco 49ers play the Los Angeles Rams Week 5 of the 2025 NFL season.

In the first four weeks of the season, the spotlight was strongly on the rookies. Thursday’s game will be about a different class of players on the 49ers roster: the “young veterans” who are squarely in the NFL’s middle class.