The Los Angeles Rams beat the San Francisco 49ers in the 2021 NFC championship game thanks in part to one artificial advantage per a former 49er.

Kyren Williams fumbles the ball at the goal line late in regulation and can't convert on fourth down in overtime in the Rams' 26-23 loss to the 49ers.

The San Francisco 49ers stayed atop the NFC West with a miracle win over the Los Angeles Rams in Week 5. Here are the highlights.

Lenoir registered six tackles (two solo) and one pass defense during the 49ers' 26-23 overtime win over the Rams. Lenoir played every single defensive snap for the third time this season, and his six tackles were fourth most on the 49ers.

To replace those departed contributors, the 49ers focused on the 2025 NFL draft and rebuilding their defense. It was a roster reimagining following a similar blueprint of the 2023 Los Angeles Rams and 2024 Buffalo Bills, both teams that Lynch says his staff spent time studying before the offseason began.

Jones threw for 342 yards and two touchdowns in the performance as the 49ers advanced to 4-1 on the season. San Francisco has now beaten all three of its divisional opponents in the 2025 season.

Rams wide receiver Puka Nacua is off to an incredible start, even by his standards, as the Rams prepare for their first divisional battle against the 49ers.

McCaffrey’s 76 snaps were the second most of his career, surpassed only by an 83-snap game in 2018 when he was with the Carolina Panthers.

Stepping into the primetime spotlight for his third start of the season, Mac Jones delivered the kind of rock-solid, efficient performance that is quickly becoming his calling card in the Kyle Shanahan offense.

Chief National Reporter Steve Wyche and NFL Network analyst Daniel Jeremiah discuss what to expect in Week 5 matchup between the San Francisco 49ers and Los Angeles Rams on "NFL Gameday Kickoff".