McCaffrey leads the NFL in touches (100), and given the short week, San Francisco may call upon Robinson more than usual, making his NFL prop bet one to consider. Before betting any 49ers vs. Rams props for Thursday Night Football,

Jones made it clear that he still views Brock Purdy as the starter, and shared his approach to the 49ers' season moving forward.

The San Francisco 49ers noted that George Kittle has only a small chance at coming back from injured reserve in time for their next game in Tampa Bay, among other injury updates.

San Francisco 49ers defensive tackle Alfred Collins, bottom, celebrates with teammates after recovering a fumble against the Los Angeles Rams during the second half of an NFL football game, Thursday, Oct. 2, 2025, in Inglewood, Calif.

The San Francisco 49ers got out to an early lead with another big game from Mac Jones, hung tough with key defensive stops and pulled off a 26-23 OT win over the Los Angeles Rams.

Just over three years ago, the San Francisco 49ers traded for running back Christian McCaffrey and altered the balance of power in the NFC West. 49ers general manager John Lynch sent the Carolina Panthers a second-round pick,

Kyle Juszczyk's wife, Kristin Juszczyk turned the San Francisco 49ers’ Week 5 clash into her own runway with a daring game day look.

The San Francisco 49ers announced they’ve promoted quarterback Adrian Martinez from the practice squad to the team’s active roster. Since it’s a promotion, Martinez is now on the 53-man roster until he’s waived. That might be another sign that this is not a temporary move, making Martinez the backup quarterback.