Bacterial fermentation products with cytostatic and antitumour activity target components of the basal precursor mRNA (pre-mRNA) splicing machinery. At least some of these drugs achieve their effects ...

CLL cells were irradiated (5Gy), cultured for 45 min or 16 h and lysed in Laemmli sample buffer and western blotting was performed using standard conditions as described previously. 26 The following ...

INTRODUCTION Currently available prognostic factors determining the course of chronic lymphocytic leukemia (CLL) are not fully efficient, especially for newly diagnosed patients. Investigation of ...

A new proof-of-concept method reliably engineered a hotspot mutation of SF3B1, a gene-splicing gene, into diverse cancer cell lines, outperforming other contemporary editing approaches. Oncogenesis ...