The San Francisco 49ers will be extremely shorthanded when they take on the Los Angeles Rams this Thursday night, that's for sure. Earlier this week, San Francisco ruled out starting quarterback Brock Purdy due to a lingering toe injury.

The San Francisco 49ers released their latest injury updates headed into the Week 5 contest versus the Los Angeles Rams.

The final injury report leading into Week 5's Thursday Night Football matchup between the Rams and the 49ers at SoFi Stadium.

The San Francisco 49ers head into Thursday Night Football against the Los Angeles Rams, with a 3-1 record, matching their division rivals. It’s a big early-season matchup, and the 49ers aren’t hiding anything,

The 49ers put 12 players on their estimated report, listing seven of them as non-participants. Brock Purdy was estimated as DNP, as were Jauan Jennings and Ricky Pearsall. Purdy isn't certain to play this week, according to coach Kyle Shanahan, so his status will be monitored in the coming days.

The Ravens practiced without quarterback Lamar Jackson, cornerbacks Marlon Humphrey and Chidobe Awuzie, linebackers Roquan Smith and Kyle Van Noy

Fantasy Impact: ESPN's Kris Rhim posits that the Chargers could be forced to lean on rookie running back Omarion Hampton in a way they "didn't anticipate" in 2025. It would certainly make sense after Hampton erupted for 135 yards from scrimmage and a touchdown against the Broncos. Hampton vaults into the RB1 tier for the remainder of the season.

The 49ers are down yet another player. Defensive tackle Kalia Davis broke his hand in Thursday night's win over the Rams, and will undergo surgery on Friday, ac