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Rams vs. 49ers: Predictions, picks, best bets for Week 5's Thursday Night Football matchup

For starters, the Rams might just be the best team in football.

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Rams vs. 49ers 2025 Prediction, Odds, Picks - Oct 2

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49ers vs. Rams predictions: Who NFL experts are picking to win NFC West showdown

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Best NFL Picks and Predictions Today (How to Bet 49ers vs. Rams on Thursday Night Football in NFL Week 5)

First place in the NFC West is up for grabs on Thursday night in Week 5, as the San Francisco 49ers hit the road to take on the Los Angeles Rams in a battle of 3-1 teams.

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49ers at Rams on TNF: Kyle Shanahan vs. Sean McVay, rivalry history and TV predictions

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5 quick takeaways from Jaguars first 4 games of NFL season

Covers.com

49ers vs Rams Predictions, Picks & Best Bets for Thursday Night Football Tonight

Our 49ers vs. Rams predictions believe Matthew Stafford and the potent Los Angeles pass attack will pull away from San Francisco on Thursday, October 2, 2025. Free NFL picks for Week 5.

USA TODAY Touchdown Wire on MSN

49ers fix huge roster issue, swap 2 picks for Saints $52 million DE in projected NFL trade

Sigler projected the 0-4 Saints to quickly become sellers ahead of the Nov. 4 trade deadline. One of his potential moves has the 49ers sending third and fourth-round picks in the 2026 draft to New Orleans in exchange for 28-year-old Northern California native Carl Granderson.

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Rams vs. 49ers score, takeaways as Mac Jones, San Francisco pull off TNF stunner

The 49ers took down the Rams in overtime in their Week 5 "Thursday Night Football" matchup. Here's how it happened.