The New Orleans Saints take on the Bills in Buffalo at noon on Sunday with the road team serving as a heavy underdog. This is the place to keep up with the score and live updates. The Bills (3-0) are 14.5-point favorites over the Saints, who are 0-3 entering the game.

The Bills committed 11 penalties but pulled away in the fourth quarter to beat the Saints. Here are the highlights.

Another home game at Highmark Stadium is on the horizon as the undefeated Buffalo Bills play host to the winless New Orleans Saints. Though the records show that the Saints don’t typically lose in Buffalo, if we were betting people, we’d probably throw all of our money on the Bills.

The Miami Dolphins and Buffalo Bills faced off in the Thursday Night Football kickoff to Week 3 of the 2025 NFL season. The AFC East rivals entered the game headed in opposite directions, with Miami looking for their first win of the year while Buffalo was looking to remain undefeated.

It’ll feel like summer in Orchard Park this weekend, but the Buffalo Bills are planning a blizzard.

The Falcons have seen a tremendous year-over-year improvement from their defense, but their post-bye week showdown with the Bills will be its biggest test yet.

ORCHARD PARK, N.Y. — Most fans probably didn't expect to see the Buffalo Bills tied late, but only four days after a road win, an AFC East rivalry matchup lived up to its historical billing. A drastic momentum change followed a roughing the punter ...

Hear from Buffalo Bills head coach Sean McDermott regarding safety Cole Bishop's crucial interception in the Week 4 win over the New Orleans Saints.