Jauan Jennings couldn’t resist having a little fun on Monday night at Lucas Oil Stadium.

Jauan Jennings reeled in a sweet touchdown catch from Brock Purdy on Monday night, and then the San Francisco 49ers ' WR ran ...

Preview the NFL week 17 matchup between the Jacksonville Jaguars and Colts, including betting odds, tips, trends, and game ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

By winning Monday night’s final regular-season road game in a 48-27 shootout over the Colts, the 49ers remained in control of ...

It all started on the kickoff after the 49ers scored their first touchdown of the game. Ameer Abdullah caught the ball, ran ...

Brock Purdy and the San Francisco 49ers spoiled Philip Rivers' return to Indianapolis, as they took down the Colts to remain ...

Purdy's career night kept the 49ers in the hunt for the NFC's top seed and dampened the Colts' already faint playoff hopes.

The Indianapolis Colts' playoff hopes took a massive blow after another loss, this time to the San Francisco 49ers.

San Francisco 49ers RB Christian McCaffrey catches a 2-yard touchdown pass from QB Brock Purdy in the team's Week 16 matchup ...