In vertebrates, the skeleton not only confers morphology, but also provides essential functions of life, including control of movements and protection of vital organs. During embryonic development, ...

The skeleton is among the most commonly injured body tissues. Every year more than 16 million fractures of long bones occur in the United States. Fortunately, bone has excellent regenerative potential ...

There are more than 200 bones in the human body. Bone is formed during embryonic and postnatal skeletogenesis by two distinct, well-organized processes, intramembranous and endochondral ossification.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 49 (Dec. 7, 2004), pp. 17300-17305 (6 pages) Guanylyl cyclase B is the receptor for a small peptide ...

Fluorescein-labeled antibodies to protein-polysaccharides from rat and calf cartilage were used for the histochemical localization of protein-polysaccharide in epiphyseal cartilage. There was less ...

Bone tissue is capable of regenerating to some extent after injury in the human body. Bone regeneration is attributed to both bone developmental pathways: intramembranous ossification and endochondral ...

Achondroplasia is a genetic disorder that inhibits endochondral ossification, resulting in disproportionate short stature and clinically significant medical complications. Vosoritide is a biologic ...

The most common sites of osteochondrosis associated with anterior knee pain occur at secondary centers including the tibial tubercle (Osgood-Schlatter disease) and/or the inferior patellar pole ...

A research team has identified the MAPK Erk5 as a novel player controlling skeletogenesis. Their research sheds light on the question of how the complex our skeleton generates. There are more than 200 ...