The 49ers found brief momentum with 3 1/2 minutes to play, after Jaguars kicker Cam Little missed a 47-yard field goal.

Trevor Lawrence, Travis Hunter and the Jacksonville Jaguars go west to face the San Francisco 49ers in Week 4 NFL football. See updates and analysis.

The Jacksonville Jaguars have one of the toughest tests in the early portion of the regular season when they take on the undefeated San Francisco 49ers in Santa ...

The Jaguars got off to a good start. Largely thanks to two takeaways from Jacksonville's defense, the Jaguars took an 11-point advantage to the locker room. They faltered a bit in the second half, but ...

Step inside San Francisco 49ers Week 2 win over the New Orleans Saints, presented by Toyota. Listen in as San Francisco 49ers LB Fred Warner was wired for sound during the team's Week 4 matchup ...

The Jacksonville Jaguars have gotten their fair share of lucky injury breaks to kick off the 2025 season, and they already got one for when they face the San Francisco 49ers in Week 4. Now, it looks ...

Death, taxes, San Francisco 49ers injuries. It's only been one week into the 2025 NFL regular season and the injury bug has taken a major chunk out of the San Francisco 49ers. Brock Purdy, George ...

SFGate writer Drew Magary is apparently not a fan of San Francisco 49ers quarterback Mac Jones. “It’s my sworn duty to tell you that you’re completely screwed,” Magary wrote. “You have no hope. Any ...

Preparation comes in different shapes and sizes, and the advantages shift on a week-to-week basis. For the Jacksonville Jaguars, this week in their matchup against the Houston Texans, they'll have ...