Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

Fading Indianapolis may also be part of a greater NFL survivor pool strategy, which sees the Colts play a struggling Titans team in a couple of weeks. The model projects the Colts to win 74% of the time, which is lower than other teams this week, making Indianapolis a team to avoid in NFL survivor pool picks. See which team to pick instead here .

Patriots vs. Bills, Broncos vs. Eagles and Buccaneers vs. Seahawks highlight the upcoming slate. Here's the full Week 5 NFL schedule.

One month of the 2025-26 NFL regular season is in the books, and now it's time to kick off October with Week 5 set to kick off on Thursday, October 2, with an NFC West showdown in primetime. The action gets underway in primetime on Prime Video when the Los Angeles Rams welcome the

With Joe Flacco getting benched this week, that means that Dillon Gabriel will now become the 41st player to start at quarterback for the Browns since they returned to the NFL in 1999. That's the most different starting quarterbacks by any team over that span (The Commanders rank second with 35 different starters).

Week 5's Thursday Night Football matchup between the Rams and 49ers will air live on Amazon Prime Video. The action will not be available on traditional TV. NFL fans can tune into the Rams vs. 49ers game live on SiriusXM channels 225 (Rams) and 226 (49ers).

Since there’s a morning matchup in London, England, the early portion of the Week 5 schedule features just six games, with matchups between 12 teams broadcast on CBS and FOX. Here’s the NFL TV map for Week 5 on Sunday’s early afternoon slate.

Cincinnati Bengals head coach Zac Taylor addresses the media ahead of his team's Week 5 game against the Detroit Lions.