Preview the Week 5 matchup between the Buffalo Bills and New England Patriots with predictions, odds, over/under, spread, betting lines and more.

New England Patriots offensive coordinator Josh McDaniels has been around the block in the AFC East. McDaniels, 49, is a longtime coach of the Pats, serving in

The unbeaten Bills host the improved Patriots on Sunday Night Football. Here's Sal Maiorana's preview of the game and his prediction.

For almost the entirety of the first two decades of the 21st century the Buffalo Bills served as the little brother of the New England Patriots. They were just beat up repeatedly, and rarely in the NFL has there been such a complete domination by one team over another for that length of time,

The New England Patriots will be working for the weekend as they take on the Buffalo Bills in their first primetime matchup of the season. The Pats and the Bills will have a divisional showdown with the world watching as the lone game to cap off the Week 5 Sunday slate, which fires up New England quarterback Drake Maye.

Get the best Patriots vs. Bills predictions ahead of Sunday Night Football from Highmark Stadium. Free NFL picks for October 5.

Defensive tackle Milton Williams returned to Patriots practice on Friday and the team is hopeful he'll be able to play on Sunday as well.

The Buffalo Bills will be the next NFL team to unveil their "Rivalries" uniform in Week 5. The Bills (4-0) host the New England Patriots (2-2) for an AFC East clash on "Sunday Night Football" at Highmark Stadium.