NFL.com's Eric Edholm breaks down three must-know storylines ahead of Thursday's prime-time game between the San Francisco 49ers and Los

Previewing Thursday night's game between the Rams and 49ers with 7 key stats to know, giving us an idea of which team might have an edge.

Game summary of the San Francisco 49ers vs. Los Angeles Rams NFL game, final score 26-23, from October 2, 2025 on ESPN.

WOODLAND HILLS, Ca. The Los Angeles Rams received big news about the 49ers' roster before their matchup on Thursday night as ESPN's Adam Schefter reported the Rams' opponent will be without multiple offensive stars. Brock Purdy (toe), Ricky Pearsall (knee), Jauan Jennings (ankle, ribs) are out Thursday night vs. the Rams," reported Schefter.

The 49ers are now 4-1, with three of their wins coming from Jones under center this season, keeping San Francisco alive in the NFC West. The former first-round quarterback has been a huge surprise this year after spending most of the last two seasons as a backup option.

Dan Orlovsky pulls receipts on Mac Jones after San Francisco 49ers’ OT win over Los Angeles Rams, revisiting his two-year-old take.

Thursday Night Football between the Los Angeles Rams and the San Francisco 49ers ended with 26-23 in overtime favoring the Niners. It was a gritty battle where every yard mattered.

To replace those departed contributors, the 49ers focused on the 2025 NFL draft and rebuilding their defense. It was a roster reimagining following a similar blueprint of the 2023 Los Angeles Rams and 2024 Buffalo Bills, both teams that Lynch says his staff spent time studying before the offseason began.