With Brock Purdy sidelined, the 49ers turned to Mac Jones. Many were skeptical, but Jones has been efficient and steady in running Shanahan’s scheme. Over his three starts, he has completed 86 of 129 passes for 904 yards,

With Purdy ruled out, Mac Jones will get the nod. Jones has played in two games, completing 53 of 80 passes (66.3%) for 563 yards and four touchdowns with just one interception. In a 26-21 win over the New Orleans Saints on Sept. 14, he completed 26 of 39 passes (66.7%) for 279 yards and three touchdowns.

USA Today's NFL experts make their picks for a Week 5 showdown between the Los Angeles Rams and San Francisco 49ers

Kyle Juszczyk's wife, Kristin Juszczyk turned the San Francisco 49ers’ Week 5 clash into her own runway with a daring game day look.

The Saints just spent a second-round pick on Tyler Shough, so theoretically, they've already made a draft-capital investment in the quarterback spot under new head coach Kellen Moore. But Shough is still a total unknown sitting behind Spencer Rattler, and odds are New Orleans will be eyeing a further restocking of the position come 2026.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

Former San Francisco 49ers second-round pick Drake Jackson has three visits lined up for next week as he attempts to make an NFL comeback after not having played in the league since 2023.

DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for San Francisco vs. Los Angeles on 'Thursday Night Football'