However, they’ve avoided the injury to their star running back that had everyone worried to start the year, but in a crucial divisional matchup on "Thursday Night Football," the 49ers’ injury report ruled out five players, including the starting quarterback and three wide receivers.

The San Francisco 49ers will be without Brock Purdy again for their Thursday Night Football matchup, but the team called up a new backup QB.

San Francisco 49ers quarterback Brock Purdy is officially out for "Thursday Night Football" against the Los Angeles Rams with a toe injury. Mac Jones is expected to start in Purdy's place.

The San Francisco 49ers head into Thursday Night Football against the Los Angeles Rams, with a 3-1 record, matching their division rivals. It’s a big early-season matchup, and the 49ers aren’t hiding anything,

Through all these injuries, the 49ers still have an impressive 3-1 record. The issue is the Rams are a very tough team, and being without this many starters and offensive weapons might lead to the team’s second straight loss of the season.

The 49ers are dealing with numerous injuries heading into their Week 5 "Thursday Night Football" matchup with the Rams. Here's a look at all of them.

As if the injury troubles haven’t been bad enough for the San Francisco 49ers lately, quarterback Brock Purdy’s toe injury could keep him out for more than Thursday’s game against the Los Angeles Rams.

The San Francisco 49ers beat the Los Angeles Rams in what looked like an improbable outcome. San Francisco was far more shorthanded than their division rivals due to injuries, but still pulled off the upset. While the team is going to be happy with the win, they will have to evaluate a new slew of injuries .

San Francisco 49ers quarterback Mac Jones was able to return after appearing to hurt his left knee in the third quarter against the Los Angeles Rams