Week 4 of the 2025 NFL season starts with a Thursday Night Football game between two NFC West teams, the Seattle Seahawks and the Arizona Cardinals. The game is set to take place at State Farm Stadium in Glendale,

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The New Orleans Saints, led by quarterback Spencer Rattler, face the Seattle Seahawks, led by quarterback Sam Darnold, on Sunday, Sept. 21, 2025 in Week 3 of the NFL season at Lumen Field in Seattle,

With Sam Darnold leading the Seahawks to a 3-1 record, they must be taken more seriously as a playoff contender.

The Los Angeles Rams are hosting the San Francisco 49ers to open Week 5 in a battle of 3-1 NFC West clubs on Thursday, Oct. 2.