Penn researchers found that psilocybin can calm brain circuits tied to pain and mood, easing both physical suffering and emotional distress in animal studies. The compound works in the anterior ...

New research shows that psilocybin, the active compound in psychedelic mushrooms, can reduce both chronic pain and pain-related depression by modulating brain circuits rather than acting at the site ...

Endophilin A1 at postsynaptic sites promotes inhibitory postsynaptic organization through interaction with gephyrin to maintain E/I balance, which is essential for the suppression of epilepsy ...