The San Francisco 49ers will be extremely shorthanded when they take on the Los Angeles Rams this Thursday night, that's for sure. Earlier this week, San Francisco ruled out starting quarterback Brock Purdy due to a lingering toe injury.

The San Francisco 49ers released their latest injury updates headed into the Week 5 contest versus the Los Angeles Rams.

The final injury report leading into Week 5's Thursday Night Football matchup between the Rams and the 49ers at SoFi Stadium.

The San Francisco 49ers head into Thursday Night Football against the Los Angeles Rams, with a 3-1 record, matching their division rivals. It’s a big early-season matchup, and the 49ers aren’t hiding anything,

Fantasy Impact: ESPN's Kris Rhim posits that the Chargers could be forced to lean on rookie running back Omarion Hampton in a way they "didn't anticipate" in 2025. It would certainly make sense after Hampton erupted for 135 yards from scrimmage and a touchdown against the Broncos. Hampton vaults into the RB1 tier for the remainder of the season.

The 49ers are down yet another player. Defensive tackle Kalia Davis broke his hand in Thursday night's win over the Rams, and will undergo surgery on Friday, ac

San Francisco 49ers tight end George Kittle is eligible to be activated off injured reserve to play in the team's Week 6 matchup with the Tampa Bay Buccaneers, but that doesn't necessarily mean a return will happen against Tampa Bay.

San Francisco 49ers defensive lineman Kalia Davis suffered a hand injury that forced his early exit in the Week 5 game against the Los Angeles Rams. While Davis is going to miss time, it won't be much.