The 49ers elevated quarterback Adrian Martinez from the practice squad on a temporary basis when Brock Purdy missed a couple of games earlier this year, but they made a different move ahead of Thursday night's game against the Rams.

The San Francisco 49ers make a major move at a key position ahead of their Thursday Night Football matchup with the Rams.

However, they’ve avoided the injury to their star running back that had everyone worried to start the year, but in a crucial divisional matchup on "Thursday Night Football," the 49ers’ injury report ruled out five players, including the starting quarterback and three wide receivers.

McCaffrey leads the NFL in touches (100), and given the short week, San Francisco may call upon Robinson more than usual, making his NFL prop bet one to consider. Before betting any 49ers vs. Rams props for Thursday Night Football,

The San Francisco 49ers announced several roster updates ahead of the Thursday Night Football game against the Los Angeles Rams. Martinez joins the active roster after the 49ers ruled out starting quarterback Brock Purdy against the Rams. Mac Jones is set to make his third start of the season, with Martinez serving as his backup.

The San Francisco 49ers added a third quarterback to their active roster, which may portend bad news for QB Brock Purdy.

The San Francisco 49ers announced they have promoted DL Robert Beal Jr. to the active roster from the team's practice squad and signed DL William Bradley-King and S Jaylen Mahoney to the practice squad. In order to make room on the practice squad, the team released DB Derrick Canteen.

The San Francisco 49ers have an opportunity to best the Los Angeles Rams in one specific area on Thursday night.

The Los Angeles Rams will try to pick themselves up in the next week after getting embarrassed by the shorthanded San Francisco 49ers on Thursday night. The Rams lost outright after being 8.5-point favorites, a disappointing loss that dropped them to 3-2 on the year.

San Francisco 49ers injury updates from the Thursday Night Football matchup against the Los Angeles Rams at SoFi Stadium.