The 49ers kept giving away their lead until finally making a stop at their 11-yard line to defeat the Rams 26-23 in overtime.

The 49ers (3-1) committed four turnovers and the Jacksonville Jaguars (3-2) had none Sunday as the Niners fell 26-21.

The San Francisco 49ers will be extremely shorthanded when they take on the Los Angeles Rams this Thursday night, that's for sure. Earlier this week, San Francisco ruled out starting quarterback Brock Purdy due to a lingering toe injury.

The final injury report leading into Week 5's Thursday Night Football matchup between the Rams and the 49ers at SoFi Stadium.

The San Francisco 49ers head into Thursday Night Football against the Los Angeles Rams, with a 3-1 record, matching their division rivals. It’s a big early-season matchup, and the 49ers aren’t hiding anything,

The 49ers put 12 players on their estimated report, listing seven of them as non-participants. Brock Purdy was estimated as DNP, as were Jauan Jennings and Ricky Pearsall. Purdy isn't certain to play this week, according to coach Kyle Shanahan, so his status will be monitored in the coming days.