Kyren Williams fumbles the ball at the goal line late in regulation and can't convert on fourth down in overtime in the Rams' 26-23 loss to the 49ers.

The fumble was forced by 49ers rookie Alfred Collins who threw a perfect punch at the football to knock it loose. If Williams had scored a touchdown, it would have put the Rams up 27-23 with just 1:05 left to play, but instead, the 49ers took over possession at their own 1-yard line.

What makes the assumption even more impressive is that San Francisco almost beat Jacksonville. They had a few ugly passes by an injured Purdy, and they allowed a punt return for a touchdown. Still, they were within one score of winning the game.

In a heart-breaking overtime loss, the Los Angeles Rams fell to the injury-riddled San Francisco 49ers 26-23 on the Thursday Night Football national stage. L.A.’s was driving for the win and in the red zone when the ’ Niners defense stoned a 4th and 1 run by Kyren Williams at the 11 yard line.

Preview the Week 5 matchup between the Los Angeles Rams and San Francisco 49ers with predictions, odds, over/under, spread, betting lines and more.

Sep 28, 2025; Inglewood, California, USA; Los Angeles Rams quarterback Matthew Stafford (9) leaves the field after the game against the Indianapolis Colts at SoFi Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images / Jayne Kamin-Oncea-Imagn Images

The 49ers’ mechanical, infuriating offensive style has in the past set up the Rams to make self-inflicted mistakes, and it often felt like that bled into every phase of the team. It was the same story Thursday as the unforced errors compounded.

Follow along for live updates from the Los Angeles Rams' Week 5 game against the San Francisco 49ers on Thursday Night Football.

The San Francisco 49ers went down to Los Angeles to take on the Rams on Thursday Night Football in Week 5. The Rams were favored heading into the game as the 49ers were dealing with all kinds of injuries on the roster. Most importantly, starting quarterback Brock Purdy was out, as were wide receivers Ricky Pearsall and Jauan Jennings.

The San Francisco 49ers got a win over the Los Angeles Rams thanks to a questionable play call from Rams head coach Sean McVay in crunch time.