San Francisco 49ers defensive tackle Alfred Collins, bottom, celebrates with teammates after recovering a fumble against the Los Angeles Rams during the second half of an NFL football game, Thursday, Oct. 2, 2025, in Inglewood, Calif.

The 49ers pulled off one of the shocking upsets of the early NFL season, ignoring multiple injuries for a 26-23 overtime victory over the Rams.

The 49ers defeated the Rams 26-23 in overtime behind a terrific performance from Mac Jones, another workmanlike effort from Christian McCaffrey, a career night from Kendrick Bourne and several clutch red zone plays from their defense.

McCaffrey’s 76 snaps were the second most of his career, surpassed only by an 83-snap game in 2018 when he was with the Carolina Panthers.

Ahead of Week 5’s Thursday Night Football matchup against the division rival Los Angeles Rams, the San Francisco 49ers found out they would have to play without star quarterback Brock Purdy yet again.

PFF graded Poona Ford and Matthew Stafford among the Los Angeles Rams' standout players against the San Francisco 49ers on Thursday night.

Our 49ers vs. Rams predictions believe Matthew Stafford and the potent Los Angeles pass attack will pull away from San Francisco on Thursday, October 2, 2025. Free NFL picks for Week 5.