NFL Week 5 begins with the Los Angeles Rams hosting the San Francisco 49ers on Thursday Night Football tonight. Start time, NFL TV schedule and how to watch.

The Rams are back on the field tonight just days after beating the Colts, hosting the 49ers at SoFi Stadium for a big Week 5 matchup.

The San Francisco 49ers and the Jacksonville Jaguars square off in Week 4 of the NFL regular season today. Here's the start time and where to watch.

Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

Week 5 practice and media schedule ahead of matchup vs. Rams, featuring Kyle Shanahan and Robert Saleh press conferences.

The NFL has made a major schedule change, flexing the 49ers-Buccaneers into a late slot and pushing down Patriots-Saints.

Fortunately, there are still a few winnable games mixed in there, and if Atlanta can avoid going 0-2 over the next two weeks, the playoffs are still on the table. Check out our predictions for all 13 remaining games on the Falcons' 2025 NFL schedule.